{"id":44002,"date":"2021-07-12T13:01:53","date_gmt":"2021-07-12T11:01:53","guid":{"rendered":"https:\/\/magazin.tu-braunschweig.de\/?post_type=kb_presseinformation&p=44002"},"modified":"2021-07-19T12:17:35","modified_gmt":"2021-07-19T10:17:35","slug":"cor-101-is-inhibiting-the-emerging-indian-variants-of-sars-cov-2-including-delta","status":"publish","type":"kb_presseinformation","link":"https:\/\/magazin.tu-braunschweig.de\/en\/pi-post\/cor-101-is-inhibiting-the-emerging-indian-variants-of-sars-cov-2-including-delta\/","title":{"rendered":"COR-101 is Inhibiting the Emerging \u201cIndian\u201d Variants of SARS-CoV-2 including \u201cDelta\u201d"},"content":{"rendered":"

The human recombinant anti-SARS-CoV-2 antibody COR-101 was developed in close cooperation of Technische Universit\u00e4t Braunschweig, the Helmholtz Centre for Infection Research (HZI) and the biotech company YUMAB GmbH in Braunschweig. The antibody is currently undergoing phase Ib\/II clinical trials for the treatment of moderate to severe COVID-19 by CORAT Therapeutics GmbH. The story of the discovery and development of this antibody was now published in the Journal “Cell Reports”<\/a>.<\/p>\n

In the first step, the genetic information of immune cells, which are producing anti-SARS-CoV-2 antibodies, was isolated from blood samples from local convalescent COVID-19 patients. The collected antibody genes are used for the construction of a phage display library. Nearly 200 unique human antibodies binding to the Receptor Binding Domain (RBD) in the spike protein of SARS-CoV-2 were discovered in the test tube using the phage display approach. In tests performed at the BSL-3 facilities of the Helmholtz Centre for Infection Research (HZI)<\/a>, 30 of these antibodies efficiently blocked the infection of cells with patient-isolated SARS-CoV-2. Antibody COR-101 showed the best neutralization activity.<\/p>\n

The efficacy of the antibody was confirmed in transgenic mice, which express the human ACE2 receptor, and syrian hamsters. Virus loads in the deep lung were efficiently reduced or completely eliminated. The atomic structure of the antibody in complex with the RBD was determined and shows that the antibody directly and broadly blocks the interaction of the RBD with the human ACE2 receptor. Significantly, COR-101 binds and inhibits the spike proteins of most recently emerging SARS-CoV-2 variants, including the \u201cIndian\u201c variants (B.1.617.1 and .3). New additional data, generated after publication in Cell Reports, indicate that even the most recent WHO variant of concern<\/a>, B.1.617.2 (\u201edelta\u201c), is also efficiently inhibited.<\/p>\n

In contrast to the antibodies, which got an emergency use authorization in the EU and are designed for the treatment of not hospitalized patients with mild symptoms, the antibody COR-101 is made to treat COVID-19 patients with moderate to severe symptoms, which are hospitalized and need urgent medical support. This was achieved by modifying a part of the antibody to avoid the activation of the immune system to prevent adverse reactions in the patients due to overshooting immune responses.<\/p>\n

Prof. Dr. Michael Hust (TU Braunschweig)<\/a>, the lead senior author of this study and co-initiator of the CORAT initiative, comments: \u201cThe COR-101 antibody development project was only possible because of the close joint collaboration of our group with the YUMAB GmbH and the HZI. I\u2019m optimistic, that this antibody will save many lives of COVID-19 patients.\u201d<\/p>\n

Dr. Maren Schubert (TU Braunschweig)<\/a>, co-senior author of this study, says: \u201cWe are proud to see the results of the research and development we started in February 2020 with the first production of SARS-CoV-2 proteins in insect cells.\u201d<\/p>\n

Prof. Dr. Stefan D\u00fcbel (TU Braunschweig)<\/a>, inventor of the antibody phage display technology, which was used to discover the antibody, and initiator of the CORAT initiative, emphasized: \u201cWe have demonstrated that we can develop effective therapeutic antibody drug candidates in a very short time. This knowledge will allow us to act faster and more specific in the next pandemic situation.\u201d<\/p>\n

Dr. Joop van den Heuvel<\/a>, structure biologist at the HZI, adds: \u201cWe are fascinated about the mode of action of this unique antibody.\u201d<\/p>\n

Prof. Dr. Dr. Luka \u010ci\u010din-\u0160ain<\/a>, head of the department \u201eViral Immunology\u201c at the HZI: \u201cCOR-101 shows the excellent capability of the Braunschweig region for translational infection research.\u201d<\/p>\n

Dr. Andr\u00e9 Frenzel, CSO of YUMAB and CORAT: \u201cWe are looking forward to see the clinical trial data of COR-101, an antibody which fills the current gap in the therapy of COVID-19 patients.\u201d<\/p>\n

About the study<\/h3>\n

The study was conducted in the core research area \u201cInfections and Therapeutics\u201d at the TU Braunschweig. Mice and hamster were used for the studies. The animal experiments took place at the HZI and FU Berlin and were conducted under strict safety and animal protection regulations.<\/p>\n","protected":false},"excerpt":{"rendered":"

The human recombinant anti-SARS-CoV-2 antibody COR-101 was developed in close … <\/p>\n","protected":false},"author":43,"featured_media":44001,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","class_list":["post-44002","kb_presseinformation","type-kb_presseinformation","status-publish","format-standard","has-post-thumbnail","hentry","kb_cat_presse-research","kb_tags-biology","kb_tags-engineering-for-health"],"acf":[],"yoast_head":"\nCOR-101 is Inhibiting the Emerging \u201cIndian\u201d Variants of SARS-CoV-2 including \u201cDelta\u201d - TU Braunschweig | Blogs<\/title>\n<meta name=\"description\" content=\"The human recombinant anti-SARS-CoV-2 antibody COR-101 was developed in close cooperation of Technische Universit\u00e4t Braunschweig, the Helmholtz Centre for\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/magazin.tu-braunschweig.de\/en\/pi-post\/cor-101-is-inhibiting-the-emerging-indian-variants-of-sars-cov-2-including-delta\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"COR-101 is Inhibiting the Emerging \u201cIndian\u201d Variants of SARS-CoV-2 including \u201cDelta\u201d - 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